FBXW7gamma R387C [nucleoplasm]

Stable Identifier
R-HSA-1602335
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
FBXW7gamma Arg387Cys, FBXW7-4 R387C, FBXW7 isoform 4 R387C
FBXW7gamma R387C [nucleoplasm] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
17646409 FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

Draetta, G, Rao, S, Sears, R, Strack, P, Tibbitts, D, Hardwick, J, Pieters, R, Look, AT, Welcker, M, Meijerink, JP, Winter, C, Grim, J, O'Neil, J, Clurman, BE

J Exp Med 2007
External Reference Information
External Reference
Gene Names
FBXW7, FBW7, FBX30, SEL10
Participates
Other forms of this molecule
Modified Residues
Name
L-arginine 387 replaced with L-cysteine
Coordinate
387
PsiMod
A protein modification that effectively removes or replaces an L-arginine.
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Interactors (21)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q13616 CUL1  3 0.919 11
 UniProt:P46531 NOTCH1  20 0.876 11
 UniProt:P01106 MYC  2 0.867 11
 UniProt:P63208 SKP1  2 0.862 12
 UniProt:P24864 CCNE1  3 0.681 7
 UniProt:P08238 HSP90AB1  6 0.536 3
 UniProt:P04198 MYCN  1 0.536 3
 UniProt:Q96BA8 CREB3L1  7 0.527 2
 UniProt:Q01201 RELB  2 0.527 2
 UniProt:Q9Y266 NUDC  4 0.527 2
 UniProt:Q00597 FANCC  2 0.519 5
 UniProt:P31749 AKT1  14 0.519 5
 UniProt:O15550 KDM6A  1 0.483 2
 UniProt:P04637 TP53  20 0.483 5
 UniProt:P48436 SOX9  1 0.483 5
 UniProt:Q00534 CDK6  3 0.471 2
 UniProt:Q16539 MAPK14  7 0.471 5
 UniProt:P11802 CDK4  3 0.471 3
 UniProt:P46527 CDKN1B  8 0.471 5
 UniProt:P24385 CCND1  4 0.471 5
 UniProt:P52333 JAK3  6 0.471 5
Cite Us!