DVL is ubiquitinated by CUL3:KLHL12:RBX1

Stable Identifier
R-HSA-1504190
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
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DVL is ubiquitinated by CUL3:KLHL12:RBX1
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CUL3:KLHL12:RBX1 polyubiquitinates Dishevelled, targeting it for degradation by the proteasome (Angers et al, 2006).

Literature References
PubMed ID Title Journal Year
16547521 The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation

Angers, S, Thorpe, CJ, Biechele, TL, Goldenberg, SJ, Zheng, N, Maccoss, MJ, Moon, RT

Nat Cell Biol 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of DVL:CUL3:KLHL12:RBX1 [cytosol]
Physical Entity
DVL:CUL3:KLHL12:RBX1 [cytosol]
Activity
ubiquitin protein ligase activity (0061630)
Orthologous Events
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Bos taurus)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Caenorhabditis elegans)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Canis familiaris)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Danio rerio)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Dictyostelium discoideum)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Drosophila melanogaster)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Gallus gallus)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Mus musculus)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Rattus norvegicus)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Sus scrofa)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Xenopus tropicalis)
Authored
Rothfels, K  (2013-05-30)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-15)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2011-08-24)