DVL is ubiquitinated by CUL3:KLHL12:RBX1

Stable Identifier
R-HSA-1504190
Type
Reaction
Species
Homo sapiens
Compartment
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CUL3:KLHL12:RBX1 polyubiquitinates Dishevelled, targeting it for degradation by the proteasome (Angers et al, 2006).

Literature References
PubMed ID Title Journal Year
16547521 The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation

Maccoss, MJ, Biechele, TL, Thorpe, CJ, Zheng, N, Angers, S, Goldenberg, SJ, Moon, RT

Nat Cell Biol 2006
Participants
Participates
Catalyst Activity

ubiquitin protein ligase activity of DVL:CUL3:KLHL12:RBX1 [cytosol]

Orthologous Events
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