DVL is ubiquitinated by CUL3:KLHL12:RBX1

Stable Identifier
R-HSA-1504190
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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DVL is ubiquitinated by CUL3:KLHL12:RBX1
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CUL3:KLHL12:RBX1 polyubiquitinates Dishevelled, targeting it for degradation by the proteasome (Angers et al, 2006).

Literature References
PubMed ID Title Journal Year
16547521 The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation

Maccoss, MJ, Biechele, TL, Thorpe, CJ, Zheng, N, Angers, S, Goldenberg, SJ, Moon, RT

Nat Cell Biol 2006
Participants
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Output
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as an event of
Catalyst Activity

ubiquitin protein ligase activity of DVL:CUL3:KLHL12:RBX1 [cytosol]

Physical Entity
DVL:CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Caenorhabditis elegans)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Canis familiaris)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Danio rerio)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Dictyostelium discoideum)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Drosophila melanogaster)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Gallus gallus)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Mus musculus)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Rattus norvegicus)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Sus scrofa)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Xenopus tropicalis)
Authored
Rothfels, K  (2013-05-29)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-14)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2011-08-23)
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