Reactome | DVL is ubiquitinated by CUL3:KLHL12:RBX1

Schema > Reaction > Entries

DVL is ubiquitinated by CUL3:KLHL12:RBX1 Show undefined attributes

catalystActivity	[CatalystActivity:11016818] ubiquitin protein ligase activity of DVL:CUL3:KLHL12:RBX1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11016820
displayName	DVL is ubiquitinated by CUL3:KLHL12:RBX1
eventOf	[Pathway:R-DDI-4641258] Degradation of DVL - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DDI-1504193] Ubiquitinated DVL is degraded by the proteasome - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Homo sapiens
input	[Complex:R-DDI-1504210] DVL:CUL3:KLHL12:RBX1 [cytosol] [DefinedSet:R-DDI-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DVL is ubiquitinated by CUL3:KLHL12:RBX1
output	[Complex:R-DDI-4652690] ub-DVL:CUL3:KLHL12:RBX1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-1504190
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-4641258] Degradation of DVL
(precedingEvent)	[BlackBoxEvent:R-DDI-1504193] Ubiquitinated DVL is degraded by the proteasome
(inferredTo)	[Reaction:R-HSA-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1

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