Reactome | DAG is acylated to TAG by DGAT1/2

DAG is acylated to TAG by DGAT1/2

Stable Identifier

R-HSA-1482889

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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At the endoplasmic reticulum (ER) membrane, diacylglycerol (DAG) is acylated and forms triacylglycerol (TAG) by the action of diacylglycerol O-acyltransferase 1 (DGAT1) tetramer or by diacylglycerol O-acyltransferase 2 (DGAT2) (Wakimoto et al. 2003, Oelkers et al. 1998, Cases et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11481335	Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members Tow, B, Stone, SJ, Voelker, T, Cases, S, Lardizabal, KD, Yen, E, Farese, RV, Zhou, P	J Biol Chem	2001
14521909	A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice Okubo, K, Mitsui, H, Imai, Y, Seishima, M, Wakimoto, K, Kawasaki, S, Chiba, H, Torii, H, Michibata, H	Biochem Biophys Res Commun	2003
9756920	Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes Billheimer, JT, Behari, A, Sturley, SL, Oelkers, P, Cromley, D	J Biol Chem	1998