DAG is acylated to TAG by DGAT1/2

Stable Identifier
R-HSA-1482889
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the endoplasmic reticulum (ER) membrane, diacylglycerol (DAG) is acylated and forms triacylglycerol (TAG) by the action of diacylglycerol O-acyltransferase 1 (DGAT1) tetramer or by diacylglycerol O-acyltransferase 2 (DGAT2) (Wakimoto et al. 2003, Oelkers et al. 1998, Cases et al. 2001).

Literature References
PubMed ID Title Journal Year
14521909 A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice

Wakimoto, K, Chiba, H, Michibata, H, Seishima, M, Kawasaki, S, Okubo, K, Mitsui, H, Torii, H, Imai, Y

Biochem Biophys Res Commun 2003
11481335 Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members

Cases, S, Stone, SJ, Zhou, P, Yen, E, Tow, B, Lardizabal, KD, Voelker, T, Farese, RV

J Biol Chem 2001
9756920 Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes

Oelkers, P, Behari, A, Cromley, D, Billheimer, JT, Sturley, SL

J Biol Chem 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
diacylglycerol O-acyltransferase activity of DGAT1/2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created