Reactome | Acyl chain remodeling of CL

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Acyl chain remodeling of CL Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
created	[InstanceEdit:1482800] Williams, MG, 2011-08-12
dbId	1482798
displayName	Acyl chain remodeling of CL
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1483206] Glycerophospholipid biosynthesis - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2063937] cardiolipin acyl-chain remodeling
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1482778] CL is hydrolyzed to MLCL by PLA2G6 (IM) - Homo sapiens [Reaction:R-HSA-1482781] MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) - Homo sapiens [Reaction:R-HSA-1482794] CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) - Homo sapiens [Reaction:R-HSA-1482850] MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) - Homo sapiens [Reaction:R-HSA-1482894] CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) - Homo sapiens [Reaction:R-HSA-1482775] MLCL is acylated to CL by HADH (IM) - Homo sapiens [BlackBoxEvent:R-HSA-1482773] MLCL transports from the IM to the ER - Homo sapiens [Reaction:R-HSA-1482861] MLCL is acylated to CL by LCLAT1 (ER) - Homo sapiens [BlackBoxEvent:R-HSA-1482857] CL transports from the ER to the IM - Homo sapiens [Reaction:R-HSA-1482759] MLCL is hydrolyzed to DLCL by PLA2G4A (IM) - Homo sapiens [BlackBoxEvent:R-HSA-1482860] DLCL transports from the IM to the ER - Homo sapiens [Reaction:R-HSA-1482867] DLCL is acylated to MLCL by LCLAT1 (ER) - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482784] The role of calcium-independent phospholipase A2 in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart [LiteratureReference:1482809] Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species [LiteratureReference:1482930] Remodeling of cardiolipin by phospholipid transacylation [LiteratureReference:1482915] Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1) [LiteratureReference:1482698] A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse [LiteratureReference:1482792] The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids [LiteratureReference:1482754] Cardiolipin hydrolysis by human phospholipases A2. The multiple enzymatic activities of human cytosolic phospholipase A2
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Acyl chain remodeling of CL
orthologousEvent	[Pathway:R-SCE-1482798] Acyl chain remodeling of CL - Saccharomyces cerevisiae [Pathway:R-SPO-1482798] Acyl chain remodeling of CL - Schizosaccharomyces pombe [Pathway:R-DDI-1482798] Acyl chain remodeling of CL - Dictyostelium discoideum [Pathway:R-CEL-1482798] Acyl chain remodeling of CL - Caenorhabditis elegans [Pathway:R-DME-1482798] Acyl chain remodeling of CL - Drosophila melanogaster [Pathway:R-GGA-1482798] Acyl chain remodeling of CL - Gallus gallus [Pathway:R-XTR-1482798] Acyl chain remodeling of CL - Xenopus tropicalis [Pathway:R-DRE-1482798] Acyl chain remodeling of CL - Danio rerio [Pathway:R-SSC-1482798] Acyl chain remodeling of CL - Sus scrofa [Pathway:R-BTA-1482798] Acyl chain remodeling of CL - Bos taurus [Pathway:R-CFA-1482798] Acyl chain remodeling of CL - Canis familiaris [Pathway:R-RNO-1482798] Acyl chain remodeling of CL - Rattus norvegicus [Pathway:R-MMU-1482798] Acyl chain remodeling of CL - Mus musculus
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1482798
summation	[Summation:1601941] Acyl chain remodeling of cardiolipin (CL) occurs in the inne...

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(hasEvent)

[Pathway:R-HSA-1483206] Glycerophospholipid biosynthesis

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