Reactome | MLCL is acylated to CL by HADH (IM)

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MLCL is acylated to CL by HADH (IM) Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524104] O-acyltransferase activity of HADH octamer [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:1482800] Williams, MG, 2011-08-12
dbId	1482775
displayName	MLCL is acylated to CL by HADH (IM)
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1482798] Acyl chain remodeling of CL - Homo sapiens
followingEvent	[Reaction:R-HSA-1482778] CL is hydrolyzed to MLCL by PLA2G6 (IM) - Homo sapiens [Reaction:R-HSA-1482794] CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) - Homo sapiens [Reaction:R-HSA-1482894] CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) - Homo sapiens
input	[SimpleEntity:R-ALL-1524038] acyl-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-1498773] MLCL [mitochondrial inner membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482915] Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1)
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	MLCL is acylated to CL by HADH (IM)
orthologousEvent	[Reaction:R-GGA-1482775] MLCL is acylated to CL by HADH (IM) - Gallus gallus [Reaction:R-CEL-1482775] MLCL is acylated to CL by HADH (IM) - Caenorhabditis elegans [Reaction:R-DME-1482775] MLCL is acylated to CL by HADH (IM) - Drosophila melanogaster [Reaction:R-XTR-1482775] MLCL is acylated to CL by HADH (IM) - Xenopus tropicalis [Reaction:R-DRE-1482775] MLCL is acylated to CL by HADH (IM) - Danio rerio [Reaction:R-SSC-1482775] MLCL is acylated to CL by HADH (IM) - Sus scrofa [Reaction:R-BTA-1482775] MLCL is acylated to CL by HADH (IM) - Bos taurus [Reaction:R-CFA-1482775] MLCL is acylated to CL by HADH (IM) - Canis familiaris [Reaction:R-RNO-1482775] MLCL is acylated to CL by HADH (IM) - Rattus norvegicus [Reaction:R-MMU-1482775] MLCL is acylated to CL by HADH (IM) - Mus musculus
output	[SimpleEntity:R-ALL-1524072] cardiolipin [mitochondrial inner membrane] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-1482778] CL is hydrolyzed to MLCL by PLA2G6 (IM) - Homo sapiens [Reaction:R-HSA-1482794] CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) - Homo sapiens [Reaction:R-HSA-1482894] CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1482775
summation	[Summation:1482866] At the inner mitochondrial membrane (IM), the trifunctional ...

Referrals

(hasEvent)	[Pathway:R-HSA-1482798] Acyl chain remodeling of CL
(precedingEvent)	[Reaction:R-HSA-1482894] CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) [Reaction:R-HSA-1482778] CL is hydrolyzed to MLCL by PLA2G6 (IM) [Reaction:R-HSA-1482794] CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)

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