Reactome | Acyl chain remodeling of CL

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Acyl chain remodeling of CL Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224247
displayName	Acyl chain remodeling of CL
eventOf	[Pathway:R-RNO-1483206] Glycerophospholipid biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2063937] cardiolipin acyl-chain remodeling
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-1482781] MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) - Rattus norvegicus [Reaction:R-RNO-1482794] CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) - Rattus norvegicus [Reaction:R-RNO-1482850] MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) - Rattus norvegicus [Reaction:R-RNO-1482894] CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) - Rattus norvegicus [Reaction:R-RNO-1482775] MLCL is acylated to CL by HADH (IM) - Rattus norvegicus [Reaction:R-RNO-1482861] MLCL is acylated to CL by LCLAT1 (ER) - Rattus norvegicus [Reaction:R-RNO-1482759] MLCL is hydrolyzed to DLCL by PLA2G4A (IM) - Rattus norvegicus [Reaction:R-RNO-1482867] DLCL is acylated to MLCL by LCLAT1 (ER) - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-1482798] Acyl chain remodeling of CL - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Acyl chain remodeling of CL
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1482798
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1483206] Glycerophospholipid biosynthesis
(inferredTo)	[Pathway:R-HSA-1482798] Acyl chain remodeling of CL

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