Reactome | Acyl chain remodeling of CL

Acyl chain remodeling of CL

Stable Identifier

R-HSA-1482798

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Acyl chain remodeling of cardiolipin (CL) occurs in the inner mitochondria membranes (IM) via hydrolysis by phopholipases and subsequent reacylation by acyltransferases. At the endoplasmic reticulum (ER) membrane the situation is more complicated with monolysocardiolipin (MLCL) involved in hydrolysis and subsequent reacylation back to CL (Zachman et al. 2010, Malhotra et al. 2009, Xu et al. 2003, Taylor & Hatch 2009, Cao et al. 2004, Zhao et al. 2009, Buckland et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
19416660	Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species Ren, M, Schlame, M, Xu, Y, Malhotra, A	Biochim Biophys Acta	2009
19075029	The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids Cao, G, Li, S, Chen, YQ, Zhao, Y, Konrad, RJ	J Lipid Res	2009
15152008	A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse Shi, Y, Lockwood, J, Liu, Y, Burn, P, Cao, J	J Biol Chem	2004
19741254	The role of calcium-independent phospholipase A2 in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart McCune, SA, Sparagna, GC, Murphy, RC, Zachman, DK, Moore, RL, Chicco, AJ	J Lipid Res	2010
19737925	Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1) Taylor, WA, Hatch, GM	J Biol Chem	2009
9487141	Cardiolipin hydrolysis by human phospholipases A2. The multiple enzymatic activities of human cytosolic phospholipase A2 Kinkaid, AR, Buckland, AG, Wilton, DC	Biochim Biophys Acta	1998
14551214	Remodeling of cardiolipin by phospholipid transacylation Schlame, M, Xu, Y, Blanck, TJ, Kelley, RI	J Biol Chem	2003