Reactome | MLCL is hydrolyzed to DLCL by PLA2G4A (IM)

Schema > Reaction > Entries

MLCL is hydrolyzed to DLCL by PLA2G4A (IM) Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524096] phospholipase A2 activity of PLA2G4A:Ca2+ [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:1482800] Williams, MG, 2011-08-12
dbId	1482759
displayName	MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1482798] Acyl chain remodeling of CL - Homo sapiens
followingEvent	[Reaction:R-HSA-1482860] DLCL transports from the IM to the ER - Homo sapiens
input	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-1498773] MLCL [mitochondrial inner membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482754] Cardiolipin hydrolysis by human phospholipases A2. The multiple enzymatic activities of human cytosolic phospholipase A2 [LiteratureReference:1482518] Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
orthologousEvent	[Reaction:R-SCE-1482759] MLCL is hydrolyzed to DLCL by PLA2G4A (IM) - Saccharomyces cerevisiae [Reaction:R-SPO-1482759] MLCL is hydrolyzed to DLCL by PLA2G4A (IM) - Schizosaccharomyces pombe [Reaction:R-GGA-1482759] MLCL is hydrolyzed to DLCL by PLA2G4A (IM) - Gallus gallus [Reaction:R-XTR-1482759] MLCL is hydrolyzed to DLCL by PLA2G4A (IM) - Xenopus tropicalis [Reaction:R-DRE-1482759] MLCL is hydrolyzed to DLCL by PLA2G4A (IM) - Danio rerio [Reaction:R-SSC-1482759] MLCL is hydrolyzed to DLCL by PLA2G4A (IM) - Sus scrofa [Reaction:R-BTA-1482759] MLCL is hydrolyzed to DLCL by PLA2G4A (IM) - Bos taurus [Reaction:R-CFA-1482759] MLCL is hydrolyzed to DLCL by PLA2G4A (IM) - Canis familiaris [Reaction:R-RNO-1482759] MLCL is hydrolyzed to DLCL by PLA2G4A (IM) - Rattus norvegicus [Reaction:R-MMU-1482759] MLCL is hydrolyzed to DLCL by PLA2G4A (IM) - Mus musculus
output	[SimpleEntity:R-ALL-1498753] DLCL [mitochondrial inner membrane] [SimpleEntity:R-ALL-1524085] LCFA(-) [mitochondrial inner membrane]
precedingEvent	[Reaction:R-HSA-1482778] CL is hydrolyzed to MLCL by PLA2G6 (IM) - Homo sapiens [Reaction:R-HSA-1482794] CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) - Homo sapiens [Reaction:R-HSA-1482894] CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1482759
summation	[Summation:1482869] At the inner mitochondrial membrane (IM), the phospholipase ...

Referrals

(hasEvent)	[Pathway:R-HSA-1482798] Acyl chain remodeling of CL
(precedingEvent)	[Reaction:R-HSA-1482860] DLCL transports from the IM to the ER