Reactome | 1-acyl LPI is acylated to PI by MBOAT7

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1-acyl LPI is acylated to PI by MBOAT7 Show undefined attributes

catalystActivity	[CatalystActivity:11016387] 1-acylglycerol-3-phosphate O-acyltransferase activity of MBOAT7 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11016389
displayName	1-acyl LPI is acylated to PI by MBOAT7
eventOf	[Pathway:R-DDI-1482922] Acyl chain remodelling of PI - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] - Dictyostelium discoideum [Reaction:R-DDI-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Dictyostelium discoideum [Reaction:R-DDI-1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13] - Dictyostelium discoideum [Reaction:R-DDI-1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12] - Dictyostelium discoideum [Reaction:R-DDI-1483219] PC is exchanged with PI by PITPNB - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Homo sapiens
input	[SimpleEntity:R-ALL-1498733] 1-acyl LPI [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	1-acyl LPI is acylated to PI by MBOAT7
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-DDI-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] - Dictyostelium discoideum [Reaction:R-DDI-1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12] - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-1482598
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-1482922] Acyl chain remodelling of PI
(precedingEvent)	[Reaction:R-DDI-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] [Reaction:R-DDI-1483219] PC is exchanged with PI by PITPNB [Reaction:R-DDI-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane [Reaction:R-DDI-1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13] [Reaction:R-DDI-1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12]
(inferredTo)	[Reaction:R-HSA-1482598] 1-acyl LPI is acylated to PI by MBOAT7

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