Reactome | PTHP is reduced to BH4 by sepiapterin reductase (SPR)

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PTHP is reduced to BH4 by sepiapterin reductase (SPR) Show undefined attributes

authored	[InstanceEdit:1497960] Jassal, B, 2011-08-17
catalystActivity	[CatalystActivity:1497839] sepiapterin reductase (NADP+) activity of p-SPR dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1475425] Jassal, B, 2011-08-08
dbId	1475414
displayName	PTHP is reduced to BH4 by sepiapterin reductase (SPR)
edited	[InstanceEdit:1497960] Jassal, B, 2011-08-17
eventOf	[Pathway:R-HSA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - Homo sapiens
followingEvent	[Reaction:R-HSA-1497824] BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle - Homo sapiens [Reaction:R-HSA-1497866] Peroxynitrite can oxidise BH4 to the BH3 radical - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-1474179] PTHP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1497769] Cloning and sequencing of cDNA encoding human sepiapterin reductase--an enzyme involved in tetrahydrobiopterin biosynthesis
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	PTHP is reduced to BH4 by sepiapterin reductase (SPR)
orthologousEvent	[Reaction:R-DDI-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Dictyostelium discoideum [Reaction:R-DME-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Drosophila melanogaster [Reaction:R-GGA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Gallus gallus [Reaction:R-XTR-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Xenopus tropicalis [Reaction:R-DRE-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Danio rerio [Reaction:R-SSC-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Sus scrofa [Reaction:R-BTA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Bos taurus [Reaction:R-CFA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Canis familiaris [Reaction:R-RNO-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Rattus norvegicus [Reaction:R-MMU-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Mus musculus
output	[SimpleEntity:R-ALL-29870] BH4 [cytosol] 2 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Homo sapiens [Reaction:R-HSA-1497853] Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II - Homo sapiens [Reaction:R-HSA-1497883] Ferrous iron reduces the BH3 radical back to BH4 - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1502545] D'Eustachio, P, 2011-08-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1475414
summation	[Summation:1497870] Sepiapterin reductase (SPR) (Ichinose et al. 1991) reduces D...

Referrals

(precedingEvent)	[Reaction:R-HSA-1497866] Peroxynitrite can oxidise BH4 to the BH3 radical [Reaction:R-HSA-1497824] BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle
(hasEvent)	[Pathway:R-HSA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation