Reactome | PTHP is reduced to BH4 by sepiapterin reductase (SPR)

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PTHP is reduced to BH4 by sepiapterin reductase (SPR) Show undefined attributes

catalystActivity	[CatalystActivity:10033154] sepiapterin reductase (NADP+) activity of p-SPR dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10033156
displayName	PTHP is reduced to BH4 by sepiapterin reductase (SPR)
eventOf	[Pathway:R-MMU-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-1474179] PTHP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PTHP is reduced to BH4 by sepiapterin reductase (SPR)
output	[SimpleEntity:R-ALL-29870] BH4 [cytosol] 2 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-MMU-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Mus musculus [Reaction:R-MMU-1497853] Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1475414
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
(inferredTo)	[Reaction:R-HSA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)

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