PTHP is reduced to BH4 by sepiapterin reductase (SPR)

Stable Identifier
R-HSA-1475414
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PTHP is reduced to BH4 by sepiapterin reductase (SPR)
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Sepiapterin reductase (SPR) (Ichinose et al. 1991) reduces DHNTP to tetrahydrobiopterin (BH4).

Literature References
PubMed ID Title Journal Year
1883349 Cloning and sequencing of cDNA encoding human sepiapterin reductase--an enzyme involved in tetrahydrobiopterin biosynthesis

Ichinose, H, Nagatsu, T, Katoh, S, Fujita, K, Sueoka, T, Titani, K

Biochem Biophys Res Commun 1991
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Catalyst Activity

sepiapterin reductase activity of p-SPR dimer [cytosol]

Physical Entity
p-SPR dimer [cytosol] (Homo sapiens)
Activity
sepiapterin reductase activity (GO:0004757)
Orthologous Events
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Bos taurus)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Canis familiaris)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Danio rerio)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Dictyostelium discoideum)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Drosophila melanogaster)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Gallus gallus)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Mus musculus)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Rattus norvegicus)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Sus scrofa)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Xenopus tropicalis)
Authored
Jassal, B  (2011-08-17)
Reviewed
D'Eustachio, P  (2011-08-23)
Created
Jassal, B  (2011-08-08)
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