PTHP is reduced to BH4 by sepiapterin reductase (SPR)

Stable Identifier
R-HSA-1475414
Type
Reaction
Species
Homo sapiens
Compartment
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Sepiapterin reductase (SPR) (Ichinose et al. 1991) reduces DHNTP to tetrahydrobiopterin (BH4).

Literature References
PubMed ID Title Journal Year
1883349 Cloning and sequencing of cDNA encoding human sepiapterin reductase--an enzyme involved in tetrahydrobiopterin biosynthesis

Ichinose, H, Nagatsu, T, Katoh, S, Fujita, K, Sueoka, T, Titani, K

Biochem Biophys Res Commun 1991
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Catalyst Activity

sepiapterin reductase activity of p-SPR dimer [cytosol]

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