Reactome | Peroxynitrite can oxidise BH4 to the BH3 radical

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Peroxynitrite can oxidise BH4 to the BH3 radical Show undefined attributes

authored	[InstanceEdit:1497960] Jassal, B, 2011-08-17
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1497774] Jassal, B, 2011-08-17
dbId	1497866
displayName	Peroxynitrite can oxidise BH4 to the BH3 radical
edited	[InstanceEdit:1497960] Jassal, B, 2011-08-17
eventOf	[Pathway:R-HSA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - Homo sapiens
input	[SimpleEntity:R-ALL-29870] BH4 [cytosol] [SimpleEntity:R-ALL-1222481] Peroxynitrite [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1497808] Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Peroxynitrite can oxidise BH4 to the BH3 radical
output	[SimpleEntity:R-ALL-1497797] BH3. [cytosol]
precedingEvent	[Reaction:R-HSA-1497878] Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-) - Homo sapiens [Reaction:R-HSA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Homo sapiens [Reaction:R-HSA-1497855] Ascorbate can reduce the BH3 radical back to BH4 - Homo sapiens [Reaction:R-HSA-1497883] Ferrous iron reduces the BH3 radical back to BH4 - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1502545] D'Eustachio, P, 2011-08-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1497866
summation	[Summation:1497802] Peroxynitrite can oxidise BH4 to the BH3 radical, further re...

Referrals

(hasEvent)

[Pathway:R-HSA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

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