Reactome | DHNTP is dephosphorylated by PTPS to PTHP

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DHNTP is dephosphorylated by PTPS to PTHP Show undefined attributes

authored	[InstanceEdit:1497960] Jassal, B, 2011-08-17
catalystActivity	[CatalystActivity:1475060] 6-pyruvoyltetrahydropterin synthase activity of p-PTPS hexamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1474182] Jassal, B, 2011-08-05
dbId	1474184
displayName	DHNTP is dephosphorylated by PTPS to PTHP
edited	[InstanceEdit:1497960] Jassal, B, 2011-08-17
eventOf	[Pathway:R-HSA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - Homo sapiens
followingEvent	[Reaction:R-HSA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Homo sapiens
input	[SimpleEntity:R-ALL-1474124] DHNTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1474178] Biosynthesis of tetrahydrobiopterin. Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from human liver [LiteratureReference:1475417] 6-Pyruvoyl tetrahydropterin synthase, an enzyme with a novel type of active site involving both zinc binding and an intersubunit catalytic triad motif; site-directed mutagenesis of the proposed active center, characterization of the metal binding site and modelling of substrate binding [LiteratureReference:1475423] Expression and characterization of recombinant human and rat liver 6-pyruvoyl tetrahydropterin synthase. Modified cysteine residues inhibit the enzyme activity [LiteratureReference:1475421] Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis [LiteratureReference:1475424] Serine 19 of human 6-pyruvoyltetrahydropterin synthase is phosphorylated by cGMP protein kinase II
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	DHNTP is dephosphorylated by PTPS to PTHP
orthologousEvent	[Reaction:R-PFA-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Plasmodium falciparum [Reaction:R-DDI-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Dictyostelium discoideum [Reaction:R-CEL-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Caenorhabditis elegans [Reaction:R-DME-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Drosophila melanogaster [Reaction:R-GGA-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Gallus gallus [Reaction:R-XTR-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Xenopus tropicalis [Reaction:R-DRE-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Danio rerio [Reaction:R-SSC-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Sus scrofa [Reaction:R-BTA-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Bos taurus [Reaction:R-RNO-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Rattus norvegicus [Reaction:R-MMU-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Mus musculus
output	[SimpleEntity:R-ALL-1475054] PPP [cytosol] [SimpleEntity:R-ALL-1474179] PTHP [cytosol]
precedingEvent	[Reaction:R-HSA-1475422] PTPS is phosphorylated by cGMP-dependant protein kinase II - Homo sapiens [Reaction:R-HSA-1474146] GCH1 reduces GTP to dihydroneopterin triphosphate - Homo sapiens
releaseDate	2011-09-20
requiredInputComponent	[SimpleEntity:R-ALL-29926] Mg2+ [cytosol]
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1502545] D'Eustachio, P, 2011-08-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1474184
summation	[Summation:1474185] 6-pyruvoyl tetrahydrobiopterin synthase (PTPS) (Takikawa et ...

Referrals

(hasEvent)	[Pathway:R-HSA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
(precedingEvent)	[Reaction:R-HSA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)

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