Reactome | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

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Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Show undefined attributes

authored	[InstanceEdit:143430] Yen, T, 2004-05-05 00:00:00
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:143430] Yen, T, 2004-05-05 00:00:00
crossReference	[DatabaseIdentifier:12819491] BioModels Database:BIOMD0000000186 [DatabaseIdentifier:12819639] BioModels Database:BIOMD0000000194 [DatabaseIdentifier:12819641] BioModels Database:BIOMD0000000193 [DatabaseIdentifier:12819493] BioModels Database:BIOMD0000000187
dbId	141444
displayName	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
eventOf	[Pathway:R-HSA-141424] Amplification of signal from the kinetochores - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-141409] Mad1 binds kinetochore - Homo sapiens [Reaction:R-HSA-141431] MAD2 associates with the Mad1 kinetochore complex - Homo sapiens [Reaction:R-HSA-141422] MAD2 converted to an inhibitory state via interaction with Mad1 - Homo sapiens [Reaction:R-HSA-141439] Release of activated MAD2 from kinetochores - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-06-22
literatureReference	[LiteratureReference:143454] The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
orthologousEvent	[Pathway:R-GGA-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - Gallus gallus [Pathway:R-XTR-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - Xenopus tropicalis [Pathway:R-DRE-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - Danio rerio [Pathway:R-SSC-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - Sus scrofa [Pathway:R-BTA-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - Bos taurus [Pathway:R-CFA-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - Canis familiaris [Pathway:R-RNO-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - Rattus norvegicus [Pathway:R-MMU-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - Mus musculus
releaseDate	2005-02-01
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-141444
summation	[Summation:143353] The signal from unattached kinetochores is amplified through...
updateTrackers	[UpdateTracker:9781134] Update Tracker - [Pathway:141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - v61:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9781134] Update Tracker - [Pathway:141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - v61:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-141424] Amplification of signal from the kinetochores