Reactome | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

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Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10825743
displayName	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
eventOf	[Pathway:R-GGA-141424] Amplification of signal from the kinetochores - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-141409] Mad1 binds kinetochore - Gallus gallus [Reaction:R-GGA-141431] MAD2 associates with the Mad1 kinetochore complex - Gallus gallus [Reaction:R-GGA-141422] MAD2 converted to an inhibitory state via interaction with Mad1 - Gallus gallus [Reaction:R-GGA-141439] Release of activated MAD2 from kinetochores - Gallus gallus
inferredFrom	[Pathway:R-HSA-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-141444
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-141424] Amplification of signal from the kinetochores
(inferredTo)	[Pathway:R-HSA-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

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