Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

Stable Identifier
R-HSA-141444
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
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The signal from unattached kinetochores is amplified through a Mad2 inhibitory signal that is propagated by the binding of Mad1 to the kinetochore, the association of Mad2 with Mad1, the conversion of Mad2 conformation to an inhibitory form through its association with Mad1 and finally the release of the inhibitory form of Mad2 from the kinetochore.
Literature References
PubMed ID Title Journal Year
14593737 The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit

Yen, TJ, Chan, GK

Prog Cell Cycle Res 2003
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Orthologous Events
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Cross References
BioModels Database
Authored
Yen, TJ  (2004-05-05)
Created
Yen, TJ  (2004-05-05)
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