Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

Stable Identifier
R-HSA-141444
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Click the image above or here to open this pathway in the Pathway Browser

The signal from unattached kinetochores is amplified through a Mad2 inhibitory signal that is propagated by the binding of Mad1 to the kinetochore, the association of Mad2 with Mad1, the conversion of Mad2 conformation to an inhibitory form through its association with Mad1 and finally the release of the inhibitory form of Mad2 from the kinetochore.

Literature References
PubMed ID Title Journal Year
14593737 The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit

Yen, TJ, Chan, GK

Prog Cell Cycle Res 2003
Participants
Events
Participates
as an event of
Orthologous Events
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Bos taurus)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Canis familiaris)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Danio rerio)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Gallus gallus)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Mus musculus)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Rattus norvegicus)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Sus scrofa)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Yen, TJ  (2004-05-05)
Created
Yen, TJ  (2004-05-05)
Cite Us!