Reactome | MAD2 converted to an inhibitory state via interaction with Mad1

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MAD2 converted to an inhibitory state via interaction with Mad1 Show undefined attributes

authored	[InstanceEdit:143430] Yen, T, 2004-05-05 00:00:00
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:143430] Yen, T, 2004-05-05 00:00:00
dbId	141422
displayName	MAD2 converted to an inhibitory state via interaction with Mad1
eventOf	[Pathway:R-HSA-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - Homo sapiens
followingEvent	[Reaction:R-HSA-141439] Release of activated MAD2 from kinetochores - Homo sapiens
input	[Complex:R-HSA-141427] Kinetochore:Mad1:MAD2 Complex [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:143448] The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	MAD2 converted to an inhibitory state via interaction with Mad1
orthologousEvent	[Reaction:R-GGA-141422] MAD2 converted to an inhibitory state via interaction with Mad1 - Gallus gallus [Reaction:R-XTR-141422] MAD2 converted to an inhibitory state via interaction with Mad1 - Xenopus tropicalis [Reaction:R-DRE-141422] MAD2 converted to an inhibitory state via interaction with Mad1 - Danio rerio [Reaction:R-SSC-141422] MAD2 converted to an inhibitory state via interaction with Mad1 - Sus scrofa [Reaction:R-BTA-141422] MAD2 converted to an inhibitory state via interaction with Mad1 - Bos taurus [Reaction:R-CFA-141422] MAD2 converted to an inhibitory state via interaction with Mad1 - Canis familiaris [Reaction:R-RNO-141422] MAD2 converted to an inhibitory state via interaction with Mad1 - Rattus norvegicus [Reaction:R-MMU-141422] MAD2 converted to an inhibitory state via interaction with Mad1 - Mus musculus
output	[Complex:R-HSA-141432] Kinetochore:Mad1:MAD2* Complex [cytosol]
precedingEvent	[Reaction:R-HSA-141431] MAD2 associates with the Mad1 kinetochore complex - Homo sapiens
releaseDate	2005-02-01
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-141422
summation	[Summation:141419] In vitro structural studies have shown that Mad2 undergoes a...

Referrals

(hasEvent)	[Pathway:R-HSA-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
(precedingEvent)	[Reaction:R-HSA-141439] Release of activated MAD2 from kinetochores

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