Reactome | MAD2 converted to an inhibitory state via interaction with Mad1

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MAD2 converted to an inhibitory state via interaction with Mad1 Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10659430
displayName	MAD2 converted to an inhibitory state via interaction with Mad1
eventOf	[Pathway:R-XTR-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-141439] Release of activated MAD2 from kinetochores - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-141422] MAD2 converted to an inhibitory state via interaction with Mad1 - Homo sapiens
input	[Complex:R-XTR-141427] Kinetochore:Mad1:MAD2 Complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MAD2 converted to an inhibitory state via interaction with Mad1
output	[Complex:R-XTR-141427] Kinetochore:Mad1:MAD2 Complex [cytosol]
precedingEvent	[Reaction:R-XTR-141431] MAD2 associates with the Mad1 kinetochore complex - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-141422
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
(precedingEvent)	[Reaction:R-XTR-141439] Release of activated MAD2 from kinetochores
(inferredTo)	[Reaction:R-HSA-141422] MAD2 converted to an inhibitory state via interaction with Mad1

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