MAD2 converted to an inhibitory state via interaction with Mad1

Stable Identifier
R-HSA-141422
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MAD2 converted to an inhibitory state via interaction with Mad1
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In vitro structural studies have shown that Mad2 undergoes a major conformational change upon binding to Mad1. This conformational change is postulated to activate Mad2 into a high affinity state which can bind and sequester Cdc20 from the APC.

Literature References
PubMed ID Title Journal Year
11804586 The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20

Yu, H, Rizo, J, Tang, Z, Luo, X

Mol Cell 2002
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Orthologous Events
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MAD2 converted to an inhibitory state via interaction with Mad1 (Danio rerio)
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MAD2 converted to an inhibitory state via interaction with Mad1 (Mus musculus)
MAD2 converted to an inhibitory state via interaction with Mad1 (Rattus norvegicus)
MAD2 converted to an inhibitory state via interaction with Mad1 (Sus scrofa)
MAD2 converted to an inhibitory state via interaction with Mad1 (Xenopus tropicalis)
Authored
Yen, TJ  (2004-05-05)
Created
Yen, TJ  (2004-05-05)
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