Reactome | Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C

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Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C Show undefined attributes

authored	[InstanceEdit:203275] Ouwehand, W.H., 2007-11-12 16:45:54
catalystActivity	[CatalystActivity:141039] serine-type endopeptidase activity of activated thrombin:thrombomodulin [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:140993] D'Eustachio, P, 2004-08-26 13:13:00
dbId	141040
displayName	Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C
eventOf	[Pathway:R-HSA-9769739] Regulation of clotting cascade - Homo sapiens [Pathway:R-HSA-202733] Cell surface interactions at the vascular wall - Homo sapiens
followingEvent	[Reaction:R-HSA-5603467] Activated protein C is released from PROCR - Homo sapiens
input	[Complex:R-HSA-5603321] PROCR:Protein C [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:141028] The roles of protein C and thrombomodulin in the regulation of blood coagulation [LiteratureReference:141045] Human plasma protein C: isolation, characterization, and mechanism of activation by alpha-thrombin [LiteratureReference:9935162] The affinity of protein C for the thrombin.thrombomodulin complex is determined in a primary way by active site-dependent interactions
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C protein C -> activated protein C + protein C heavy chain activation peptide
orthologousEvent	[Reaction:R-SSC-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - Sus scrofa [Reaction:R-BTA-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - Bos taurus [Reaction:R-CFA-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - Canis familiaris [Reaction:R-RNO-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - Rattus norvegicus [Reaction:R-MMU-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-141051] PROC(200-211) [extracellular region] [Complex:R-HSA-5603469] PROCR:Activated protein C [plasma membrane]
precedingEvent	[Reaction:R-HSA-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin - Homo sapiens [Reaction:R-HSA-5591052] PROCR binds Protein C - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-203103] Positive regulation by 'Platelet Factor 4 [extracellular region]'
regulationReference	[RegulationReference:9641746] Positive regulation by 'Platelet Factor 4 [extracellular region]' Platelet factor 4 modulation of the thrombomodulin-protein C system
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:203274] Zwaginga, JJ, 2007-11-12 16:47:00
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-141040
summation	[Summation:141044] Thrombin complexed with thrombomodulin at the endothelial ce...
updateTrackers	[UpdateTracker:9792174] Update Tracker - [Reaction:141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - v23:[addRegulator] [UpdateTracker:9939789] Update Tracker - [Reaction:141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - v92:[removeLiteratureReference] [UpdateTracker:9786074] Update Tracker - [Reaction:141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - v50:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9792174] Update Tracker - [Reaction:141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - v23:[addRegulator] [UpdateTracker:9939789] Update Tracker - [Reaction:141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - v92:[removeLiteratureReference] [UpdateTracker:9786074] Update Tracker - [Reaction:141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - v50:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-9769739] Regulation of clotting cascade [Pathway:R-HSA-202733] Cell surface interactions at the vascular wall
(precedingEvent)	[Reaction:R-HSA-5603467] Activated protein C is released from PROCR

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