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Schema
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Reaction
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Entries
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C
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authored
[InstanceEdit:203275] Ouwehand, W.H., 2007-11-12 16:45:54
catalystActivity
[CatalystActivity:141039] serine-type endopeptidase activity of activated thrombin:thrombomodulin [plasma membrane]
category
transition
compartment
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:140993] D'Eustachio, P, 2004-08-26 13:13:00
dbId
141040
displayName
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C
eventOf
[Pathway:R-HSA-140875] Common Pathway of Fibrin Clot Formation - Homo sapiens
[Pathway:R-HSA-202733] Cell surface interactions at the vascular wall - Homo sapiens
followingEvent
[Reaction:R-HSA-5603467] Activated protein C is released from PROCR - Homo sapiens
input
[Complex:R-HSA-5603321] PROCR:Protein C [plasma membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:141028] The roles of protein C and thrombomodulin in the regulation of blood coagulation
[LiteratureReference:141045] Human plasma protein C: isolation, characterization, and mechanism of activation by alpha-thrombin
modified
[InstanceEdit:10314670] Wright, Adam, 2024-03-07
name
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C
protein C -> activated protein C + protein C heavy chain activation peptide
orthologousEvent
[Reaction:R-CFA-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - Canis familiaris
[Reaction:R-SSC-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - Sus scrofa
[Reaction:R-BTA-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - Bos taurus
[Reaction:R-RNO-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - Rattus norvegicus
[Reaction:R-MMU-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - Mus musculus
output
[EntityWithAccessionedSequence:R-HSA-141051] PROC(200-211) [extracellular region]
[Complex:R-HSA-5603469] PROCR:Activated protein C [plasma membrane]
precedingEvent
[Reaction:R-HSA-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin - Homo sapiens
[Reaction:R-HSA-5591052] PROCR binds Protein C - Homo sapiens
regulatedBy
[PositiveRegulation:R-HSA-203103] Positive regulation by 'Platelet Factor 4 [extracellular region]'
regulationReference
[RegulationReference:9641746] Positive regulation by 'Platelet Factor 4 [extracellular region]' Platelet factor 4 modulation of the thrombomodulin-protein C system
releaseDate
2007-12-11
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:203274] Zwaginga, JJ, 2007-11-12 16:47:00
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-141040
summation
[Summation:141044] Thrombin complexed with thrombomodulin at the endothelial ce...
Referrals
(hasEvent)
[Pathway:R-HSA-140875] Common Pathway of Fibrin Clot Formation
[Pathway:R-HSA-202733] Cell surface interactions at the vascular wall
(precedingEvent)
[Reaction:R-HSA-5603467] Activated protein C is released from PROCR
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