Reactome | activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin

Schema > Reaction > Entries

activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin Show undefined attributes

authored	[InstanceEdit:140993] D'Eustachio, P, 2004-08-26 13:13:00
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:140993] D'Eustachio, P, 2004-08-26 13:13:00
dbId	141046
displayName	activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin
eventOf	[Pathway:R-HSA-140875] Common Pathway of Fibrin Clot Formation - Homo sapiens
followingEvent	[Reaction:R-HSA-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - Homo sapiens
input	[Complex:R-HSA-156786] activated thrombin (factor IIa) [extracellular region] [EntityWithAccessionedSequence:R-HSA-141030] THBD [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:141028] The roles of protein C and thrombomodulin in the regulation of blood coagulation
modified	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
name	activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin
orthologousEvent	[Reaction:R-CFA-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin - Canis familiaris [Reaction:R-SSC-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin - Sus scrofa [Reaction:R-BTA-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin - Bos taurus [Reaction:R-RNO-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin - Rattus norvegicus [Reaction:R-MMU-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin - Mus musculus
output	[Complex:R-HSA-141038] activated thrombin:thrombomodulin [plasma membrane]
precedingEvent	[Reaction:R-HSA-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - Homo sapiens
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-141046
summation	[Summation:141047] Activated thrombin (factor IIa) binds to thrombomodulin at t...

Referrals

(hasEvent)	[Pathway:R-HSA-140875] Common Pathway of Fibrin Clot Formation
(precedingEvent)	[Reaction:R-HSA-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C

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