Reactome | Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C

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Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C Show undefined attributes

catalystActivity	[CatalystActivity:10342438] serine-type endopeptidase activity of activated thrombin:thrombomodulin [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10342446
displayName	Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C
eventOf	[Pathway:R-BTA-9769739] Regulation of clotting cascade - Bos taurus [Pathway:R-BTA-202733] Cell surface interactions at the vascular wall - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5603467] Activated protein C is released from PROCR - Bos taurus
inferredFrom	[Reaction:R-HSA-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - Homo sapiens
input	[Complex:R-BTA-5603321] PROCR:Protein C [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C protein C -> activated protein C + protein C heavy chain activation peptide
output	[EntityWithAccessionedSequence:R-BTA-141051] PROC [extracellular region] [Complex:R-BTA-5603469] PROCR:Activated protein C [plasma membrane]
precedingEvent	[Reaction:R-BTA-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin - Bos taurus [Reaction:R-BTA-5591052] PROCR binds Protein C - Bos taurus
regulatedBy	[PositiveRegulation:10342447] Positive regulation by 'Platelet Factor 4 [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-141040
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9769739] Regulation of clotting cascade [Pathway:R-BTA-202733] Cell surface interactions at the vascular wall
(precedingEvent)	[Reaction:R-BTA-5603467] Activated protein C is released from PROCR
(inferredTo)	[Reaction:R-HSA-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C

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