Reactome | Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C

Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C

Stable Identifier

R-HSA-141040

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

protein C -> activated protein C + protein C heavy chain activation peptide

ReviewStatus

5/5

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Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C

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Thrombin complexed with thrombomodulin at the endothelial cell surface cleaves the heavy chain of protein C, generating activated protein C and an activation peptide. The activation peptide has no known function.

Literature References

PubMed ID	Title	Journal	Year
15705565	The affinity of protein C for the thrombin.thrombomodulin complex is determined in a primary way by active site-dependent interactions Lu, G, Chhum, S, Krishnaswamy, S	J Biol Chem	2005
468991	Human plasma protein C: isolation, characterization, and mechanism of activation by alpha-thrombin Kisiel, W	J Clin Invest	1979
2538457	The roles of protein C and thrombomodulin in the regulation of blood coagulation Esmon, CT	J Biol Chem	1989