Reactome | factor Va + factor Xa -> Va:Xa complex (prothrombinase)

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factor Va + factor Xa -> Va:Xa complex (prothrombinase) Show undefined attributes

authored	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
dbId	140686
displayName	factor Va + factor Xa -> Va:Xa complex (prothrombinase)
eventOf	[Pathway:R-HSA-9769743] Amplification and propagation of coagulation cascade - Homo sapiens [Pathway:R-HSA-9769735] Initiation of coagulation cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - Homo sapiens
input	[Complex:R-HSA-140692] factor Va [extracellular region] [Complex:R-HSA-140689] factor Xa [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:140650] Cofactor proteins in the assembly and expression of blood clotting enzyme complexes [LiteratureReference:9930537] Blood coagulation factor Va's key interactive residues and regions for prothrombinase assembly and prothrombin binding [LiteratureReference:9930565] Factor Va-factor Xa interactions: molecular sites involved in enzyme:cofactor assembly [LiteratureReference:9930542] Defining the factor Xa-binding site on factor Va by site-directed glycosylation [LiteratureReference:9930777] Membrane-dependent interaction of factor Xa and prothrombin with factor Va in the prothrombinase complex [LiteratureReference:9930776] Cryo-EM structure of the prothrombin-prothrombinase complex [LiteratureReference:9930775] Cryo-EM structures of coagulation factors
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	factor Va + factor Xa -> Va:Xa complex (prothrombinase)
orthologousEvent	[Reaction:R-MMU-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - Mus musculus [Reaction:R-DRE-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - Danio rerio [Reaction:R-BTA-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - Bos taurus [Reaction:R-GGA-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - Gallus gallus [Reaction:R-SSC-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - Sus scrofa [Reaction:R-CFA-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - Canis familiaris
output	[Complex:R-HSA-140662] FVa:FXa [plasma membrane]
precedingEvent	[Reaction:R-HSA-9930792] factor Va intermediate -> factor Va - Homo sapiens [Reaction:R-HSA-9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa - Homo sapiens [Reaction:R-HSA-158164] factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) - Homo sapiens [Reaction:R-HSA-140696] factor V -> factor Va + factor V activation peptide (thrombin catalyst) - Homo sapiens
releaseDate	2004-10-27
requiredInputComponent	[SimpleEntity:R-ALL-74112] Ca2+ [extracellular region]
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-140686
summation	[Summation:140693] In the presence of calcium ions (Ca�?), factor Va (FVa) and ...
updateTrackers	[UpdateTracker:9939735] Update Tracker - [Reaction:140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - v92:[modifyText, removeLiteratureReference] [UpdateTracker:9846687] Update Tracker - [Reaction:140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - v84:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9939735] Update Tracker - [Reaction:140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - v92:[modifyText, removeLiteratureReference] [UpdateTracker:9846687] Update Tracker - [Reaction:140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - v84:[modifyText]
(hasEvent)	[Pathway:R-HSA-9769743] Amplification and propagation of coagulation cascade [Pathway:R-HSA-9769735] Initiation of coagulation cascade
(precedingEvent)	[Reaction:R-HSA-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)

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