Reactome | Initiation of coagulation cascade

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Initiation of coagulation cascade Show undefined attributes

authored	[InstanceEdit:9769736] Shamovsky, Veronica, 2022-03-22
created	[InstanceEdit:9769736] Shamovsky, Veronica, 2022-03-22
dbId	9769735
displayName	Initiation of coagulation cascade
edited	[InstanceEdit:9938586] Shamovsky, Veronica, 2025-02-18
eventOf	[Pathway:R-HSA-9769740] Coagulation pathway - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-140761] sequestered tissue factor -> tissue factor - Homo sapiens [Reaction:R-HSA-140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - Homo sapiens [Reaction:R-HSA-9822513] TF:FVII+FX -> TF:FVII:FXa + FX activation peptide (TF:F7 catalyst) - Homo sapiens [Reaction:R-HSA-9929060] TF:FVII:FXa ->TF:FVIIa:FXa (FXa catalyst) - Homo sapiens [Reaction:R-HSA-9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa - Homo sapiens [Reaction:R-HSA-9822514] TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst) - Homo sapiens [Reaction:R-HSA-140769] factor VII -> factor VIIa - Homo sapiens [Reaction:R-HSA-140748] tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex - Homo sapiens [Reaction:R-HSA-9929051] TF:FVIIa+FIX -> TF:FVIIa:FIXa + FIX activation peptide (TF:F7a catalyst) - Homo sapiens [Reaction:R-HSA-9929054] TF:FVIIa:FIXa ->TF:FVIIa + FIXa - Homo sapiens [Reaction:R-HSA-9822522] factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst) - Homo sapiens [Reaction:R-HSA-9769737] factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst) - Homo sapiens [Reaction:R-HSA-9930790] factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst) - Homo sapiens [Reaction:R-HSA-9933742] factor Va intermediate + factor Xa -> factor Va intermediate:factor Xa - Homo sapiens [Reaction:R-HSA-9930792] factor Va intermediate -> factor Va - Homo sapiens [Reaction:R-HSA-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - Homo sapiens [Reaction:R-HSA-140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) - Homo sapiens [Reaction:R-HSA-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9818842] Advances in understanding the molecular mechanisms that maintain normal haemostasis
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Initiation of coagulation cascade
orthologousEvent	[Pathway:R-GGA-9769735] Initiation of coagulation cascade - Gallus gallus [Pathway:R-XTR-9769735] Initiation of coagulation cascade - Xenopus tropicalis [Pathway:R-DRE-9769735] Initiation of coagulation cascade - Danio rerio [Pathway:R-SSC-9769735] Initiation of coagulation cascade - Sus scrofa [Pathway:R-BTA-9769735] Initiation of coagulation cascade - Bos taurus [Pathway:R-CFA-9769735] Initiation of coagulation cascade - Canis familiaris [Pathway:R-RNO-9769735] Initiation of coagulation cascade - Rattus norvegicus [Pathway:R-MMU-9769735] Initiation of coagulation cascade - Mus musculus
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9769735
summation	[Summation:9820672] The initiation phase of coagulation proceeds through the tis...

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[Pathway:R-HSA-9769740] Coagulation pathway

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