factor Va + factor Xa -> Va:Xa complex (prothrombinase)

Stable Identifier
R-HSA-140686
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Factors Va and Xa associate on a membrane surface to form a complex in which the activity of factor Xa on prothrombin is greatly increased (Mann et al. 1988). The presence of negatively charged phospholipid in the membrane greatly facilitates this process, a feature that may contribute to its localization, as such phospholipids are normally on the cytosolic face of the plasma membrane (Devaux 1992), but could be exposed to the extracellular space following platelet activation or mechanical injury to endothelial cells.

Literature References
PubMed ID Title Journal Year
3052293 Cofactor proteins in the assembly and expression of blood clotting enzyme complexes

Mann, KG, Jenny, RJ, Krishnaswamy, S

Annu Rev Biochem 1988
Participants
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Orthologous Events
Authored
Created