factor Va + factor Xa -> Va:Xa complex (prothrombinase)

Stable Identifier
R-HSA-140686
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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factor Va + factor Xa -> Va:Xa complex (prothrombinase)
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Factors Va and Xa associate on a membrane surface to form a complex in which the activity of factor Xa on prothrombin is greatly increased (Mann et al. 1988). The presence of negatively charged phospholipid in the membrane greatly facilitates this process, a feature that may contribute to its localization, as such phospholipids are normally on the cytosolic face of the plasma membrane (Devaux 1992), but could be exposed to the extracellular space following platelet activation or mechanical injury to endothelial cells.
Literature References
PubMed ID Title Journal Year
3052293 Cofactor proteins in the assembly and expression of blood clotting enzyme complexes

Krishnaswamy, S, Jenny, RJ, Mann, KG

Annu Rev Biochem 1988
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Orthologous Events
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Bos taurus)
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Canis familiaris)
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Danio rerio)
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Gallus gallus)
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Mus musculus)
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Sus scrofa)
Authored
D'Eustachio, P  (2004-08-24)
Created
D'Eustachio, P  (2004-08-24)
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