Reactome | factor Va + factor Xa -> Va:Xa complex (prothrombinase)

Schema > Reaction > Entries

factor Va + factor Xa -> Va:Xa complex (prothrombinase) Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10456052
displayName	factor Va + factor Xa -> Va:Xa complex (prothrombinase)
eventOf	[Pathway:R-SSC-9769743] Amplification and propagation of coagulation cascade - Sus scrofa [Pathway:R-SSC-9769735] Initiation of coagulation cascade - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - Sus scrofa
inferredFrom	[Reaction:R-HSA-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - Homo sapiens
input	[Complex:R-SSC-140692] factor Va [extracellular region] [Complex:R-SSC-140689] factor Xa [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	factor Va + factor Xa -> Va:Xa complex (prothrombinase)
output	[Complex:R-SSC-140662] FVa:FXa [plasma membrane]
precedingEvent	[Reaction:R-SSC-9930792] factor Va intermediate -> factor Va - Sus scrofa [Reaction:R-SSC-9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa - Sus scrofa [Reaction:R-SSC-140696] factor V -> factor Va + factor V activation peptide (thrombin catalyst) - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-140686
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9769743] Amplification and propagation of coagulation cascade [Pathway:R-SSC-9769735] Initiation of coagulation cascade
(precedingEvent)	[Reaction:R-SSC-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
(inferredTo)	[Reaction:R-HSA-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase)