Reactome | factor Va [extracellular region]

Schema > Complex > Entries

compartment	[Compartment:984] extracellular region
consumedByEvent	[Reaction:R-HSA-141026] Activated protein C cleaves factor Va to factor Vi intermediate form - Homo sapiens [Reaction:R-HSA-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - Homo sapiens
created	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
dbId	140692
displayName	factor Va [extracellular region]
hasComponent	[SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] [EntityWithAccessionedSequence:R-HSA-140691] factor Va heavy chain [extracellular region] [EntityWithAccessionedSequence:R-HSA-140690] factor Va light chain [extracellular region]
inDisease	false
inferredTo	[Complex:R-MMU-140692] factor Va [extracellular region] - Mus musculus [Complex:R-CFA-140692] factor Va [extracellular region] - Canis familiaris [Complex:R-BTA-140692] factor Va [extracellular region] - Bos taurus [Complex:R-SSC-140692] factor Va [extracellular region] - Sus scrofa [Complex:R-DRE-140692] factor Va [extracellular region] - Danio rerio [Complex:R-GGA-140692] factor Va [extracellular region] - Gallus gallus
maxDepth	2
name	factor Va
producedByEvent	[Reaction:R-HSA-9930792] factor Va intermediate -> factor Va - Homo sapiens [Reaction:R-HSA-140696] factor V -> factor Va + factor V activation peptide (thrombin catalyst) - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-140692

(normalEntity)	[EntityFunctionalStatus:9930431] loss_of_function of FV R534Q, FV A540V [extracellular region]
(input)	[Reaction:R-HSA-141026] Activated protein C cleaves factor Va to factor Vi intermediate form [Reaction:R-HSA-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase)
(output)	[Reaction:R-HSA-9930792] factor Va intermediate -> factor Va [Reaction:R-HSA-140696] factor V -> factor Va + factor V activation peptide (thrombin catalyst)

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