Reactome | PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[BlackBoxEvent:R-DRE-1170539] Prolactin receptor is internalized - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10590946
displayName	PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane]
hasComponent	[Complex:R-DRE-206748] BTRC:CUL1:RBX1:SKP1 [cytosol] [Complex:R-DRE-1977946] PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - Homo sapiens
maxDepth	6
name	PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex
negativelyRegulates	[NegativeRegulation:10590949] Negative regulation by 'PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane]'
producedByEvent	[Reaction:R-DRE-1370500] PRLR binds SCF beta-TrCP complex - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-1369085
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[BlackBoxEvent:R-DRE-1170539] Prolactin receptor is internalized
(output)	[Reaction:R-DRE-1370500] PRLR binds SCF beta-TrCP complex
(regulator)	[NegativeRegulation:10590949] Negative regulation by 'PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane]'
(inferredTo)	[Complex:R-HSA-1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane]

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