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p-T,Y MAPK dimers [cytosol]
Stable Identifier
R-HSA-1268261
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-ERK dimer
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
Constitutive phosphorylation by pERK1/2 (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
MAPK-dependent phosphorylation of KARS (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Signaling by NODAL (Homo sapiens)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by LTK in cancer (Homo sapiens)
CLIP1-LTK promotes MAPK1 and MAPK3 phosphorylation (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon gamma signaling (Homo sapiens)
IFNG signaling activates MAPKs (Homo sapiens)
JAK1-activated RAF1 phosphorylates MAPKs (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
JAK2-activated MAPKs phosphorylate YBX1 (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
RSK activation (Homo sapiens)
ERKs phosphorylate RSKs (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Apoptotic factor-mediated response (Homo sapiens)
Cytochrome c-mediated apoptotic response (Homo sapiens)
Formation of apoptosome (Homo sapiens)
Regulation of the apoptosome activity (Homo sapiens)
CASP9 is phosphorylated at T412 (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
IER3 recruits MAPKs to PP2A-B56-beta,gamma (Homo sapiens)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
MAPKs phosphorylate PP2A (Homo sapiens)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
JUN binds the PTEN gene promoter (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF-independent MAPK1/3 activation (Homo sapiens)
Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
PEA15 binds MAPK monomers and dimers (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Phosphorylated MAPKs translocate into the nucleus (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs dimerize (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Negative feedback regulation of MAPK pathway (Homo sapiens)
Activated MAPK phosphorylates RAF1 (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Activated MAPKs phosphorylate BRAF (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Activated MAPKs phosphorylate MAP2K1 (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
PTPN7 binds p-T,Y-MAPK (Homo sapiens)
PTPN7:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
PTPN7 dephosphorylates p-T,Y-MAPKs (Homo sapiens)
PTPN7:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
PEA15 binds MAPK monomers and dimers (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Phosphorylated MAPKs translocate into the nucleus (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Homo sapiens)
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs dimerize (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Negative regulation of FGFR1 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
SPRY2 is serine phosphorylated in response to MAPK activation (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
Negative regulation of FGFR2 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
SPRY2 is serine phosphorylated in response to MAPK activation (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Signaling by FGFR3 (Homo sapiens)
Negative regulation of FGFR3 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
SPRY2 is serine phosphorylated in response to MAPK activation (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Negative regulation of FGFR4 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
SPRY2 is serine phosphorylated in response to MAPK activation (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Prolonged ERK activation events (Homo sapiens)
Frs2-mediated activation (Homo sapiens)
p-T,Y MAPK dimers translocate to nucleus (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
p-T,Y MAPKs dimerize (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate NADPH Oxidases (Homo sapiens)
MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by Activin (Homo sapiens)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Participants
members
p-T202, Y204 MAPK3 dimer [cytosol]
(Homo sapiens)
p-T185,Y187 MAPK1 dimer [cytosol]
(Homo sapiens)
Participates
as an input of
PTPN7 binds p-T,Y-MAPK (Homo sapiens)
IER3 recruits MAPKs to PP2A-B56-beta,gamma (Homo sapiens)
p-T,Y MAPK dimers translocate to nucleus (Homo sapiens)
as a component of
PTPN7:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
as an output of
MAPKs phosphorylate PP2A (Homo sapiens)
JAK1-activated RAF1 phosphorylates MAPKs (Homo sapiens)
p-T,Y MAPKs dimerize (Homo sapiens)
as a member of
p-T,Y MAPK monomers and dimers [cytosol] (Homo sapiens)
This entity regulates
Negatively
The SMAD2/3:SMAD4 complex transfers to the nucleus
(Homo sapiens)
Positively
SPRY2 is serine phosphorylated in response to MAPK activation
(Homo sapiens)
JUN binds the PTEN gene promoter
(Homo sapiens)
Inferred To
p-T,Y MAPK dimers [cytosol]
(Bos taurus)
p-T,Y MAPK dimers [cytosol]
(Caenorhabditis elegans)
p-T,Y MAPK dimers [cytosol]
(Canis familiaris)
p-T,Y MAPK dimers [cytosol]
(Danio rerio)
p-T,Y MAPK dimers [cytosol]
(Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol]
(Drosophila melanogaster)
p-T,Y MAPK dimers [cytosol]
(Mus musculus)
p-T,Y MAPK dimers [cytosol]
(Plasmodium falciparum)
p-T,Y MAPK dimers [cytosol]
(Rattus norvegicus)
p-T,Y MAPK dimers [cytosol]
(Saccharomyces cerevisiae)
p-T,Y MAPK dimers [cytosol]
(Schizosaccharomyces pombe)
p-T,Y MAPK dimers [cytosol]
(Sus scrofa)
p-T185,Y187 MAPK1 dimer [cytosol]
(Gallus gallus)
p-T185,Y187 MAPK1 dimer [cytosol]
(Xenopus tropicalis)
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