Reactome | Mitochondrial protein import

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Mitochondrial protein import Show undefined attributes

authored	[InstanceEdit:1258402] May, B, 2011-05-03
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:17927] mitochondrial intermembrane space [Compartment:5460] mitochondrial matrix [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:1268021] May, B, 2011-05-09
dbId	1268020
displayName	Mitochondrial protein import
edited	[InstanceEdit:1258402] May, B, 2011-05-03
eventOf	[TopLevelPathway:R-HSA-9609507] Protein localization - Homo sapiens
figure	[Figure:2463866] /figures/Pathway_Illustrations/MPI_72_oicr.png
goBiologicalProcess	[GO_BiologicalProcess:422648] protein localization to mitochondrion
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-1268022] TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space - Homo sapiens [Reaction:R-HSA-1307802] MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds - Homo sapiens [Reaction:R-HSA-1299484] TIMM8:TIMM13 chaperones hydrophobic proteins - Homo sapiens [Reaction:R-HSA-1299481] TIMM9:TIMM10 binds hydrophobic proteins - Homo sapiens [Reaction:R-HSA-1955380] TIMM9:TIMM10 transfers proteins to TIMM22 - Homo sapiens [Reaction:R-HSA-1268025] SAM50 complex inserts proteins into mitochondrial outer membrane - Homo sapiens [Reaction:R-HSA-1307803] TIMM22 inserts proteins into inner membrane - Homo sapiens [Reaction:R-HSA-1299487] Precursor proteins enter TIMM23 SORT - Homo sapiens [Reaction:R-HSA-1299476] MPP cleaves targeting peptide (presequence) of inner membrane precursors - Homo sapiens [Reaction:R-HSA-1299482] TIMM23 SORT inserts proteins into inner membrane - Homo sapiens [Reaction:R-HSA-1299480] Precursor proteins enter TIMM23 PAM - Homo sapiens [Reaction:R-HSA-1299478] MPP cleaves targeting peptide (presequence) of matrix precursors - Homo sapiens [Reaction:R-HSA-1299475] TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix - Homo sapiens [BlackBoxEvent:R-HSA-8986181] PITRM1 proteolyzes mitochondrial targeting peptides (presequences) - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-09-30
literatureReference	[LiteratureReference:1307738] Multiple pathways for mitochondrial protein traffic [LiteratureReference:1307772] Diverse mechanisms and machineries for import of mitochondrial proteins [LiteratureReference:1307732] Oxidative protein folding in the mitochondrial intermembrane space [LiteratureReference:1307751] Disulphide bond formation in the intermembrane space of mitochondria [LiteratureReference:1307775] On the mechanism of preprotein import by the mitochondrial presequence translocase [LiteratureReference:1307739] Multiple pathways for sorting mitochondrial precursor proteins [LiteratureReference:1307740] Cooperation of translocase complexes in mitochondrial protein import [LiteratureReference:1307763] The MIA system for protein import into the mitochondrial intermembrane space [LiteratureReference:1252288] Roles of Tom70 in import of presequence-containing mitochondrial proteins [LiteratureReference:9609511] Mitochondrial protein transport in health and disease [LiteratureReference:9609509] Mitochondrial Machineries for Protein Import and Assembly
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Mitochondrial protein import
orthologousEvent	[Pathway:R-RNO-1268020] Mitochondrial protein import - Rattus norvegicus [Pathway:R-MMU-1268020] Mitochondrial protein import - Mus musculus [Pathway:R-CFA-1268020] Mitochondrial protein import - Canis familiaris [Pathway:R-BTA-1268020] Mitochondrial protein import - Bos taurus [Pathway:R-SSC-1268020] Mitochondrial protein import - Sus scrofa [Pathway:R-DRE-1268020] Mitochondrial protein import - Danio rerio [Pathway:R-XTR-1268020] Mitochondrial protein import - Xenopus tropicalis [Pathway:R-GGA-1268020] Mitochondrial protein import - Gallus gallus [Pathway:R-DME-1268020] Mitochondrial protein import - Drosophila melanogaster [Pathway:R-CEL-1268020] Mitochondrial protein import - Caenorhabditis elegans [Pathway:R-DDI-1268020] Mitochondrial protein import - Dictyostelium discoideum [Pathway:R-SPO-1268020] Mitochondrial protein import - Schizosaccharomyces pombe [Pathway:R-SCE-1268020] Mitochondrial protein import - Saccharomyces cerevisiae [Pathway:R-PFA-1268020] Mitochondrial protein import - Plasmodium falciparum
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1914221] D'Eustachio, P, 2011-11-01 [InstanceEdit:2108993] Endo, T, 2012-02-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1268020
summation	[Summation:1307730] A human mitochondrion contains about 1500 proteins, more tha...
updateTrackers	[UpdateTracker:9780310] Update Tracker - [Pathway:1268020] Mitochondrial protein import - v63:[addHasEvent, updateContainedRLE] [UpdateTracker:9779010] Update Tracker - [Pathway:1268020] Mitochondrial protein import - v66:[addLiteratureReference, modifyText] [UpdateTracker:9781349] Update Tracker - [Pathway:1268020] Mitochondrial protein import - v61:[updateContainedRLE] [UpdateTracker:9783868] Update Tracker - [Pathway:1268020] Mitochondrial protein import - v55:[updateContainedRLE]

Referrals

(hasEvent)	[TopLevelPathway:R-HSA-9609507] Protein localization
(hasEncapsulatedEvent)	[Pathway:R-HSA-1592230] Mitochondrial biogenesis [Pathway:R-HSA-9864848] Complex IV assembly
(updatedInstance)	[UpdateTracker:9780310] Update Tracker - [Pathway:1268020] Mitochondrial protein import - v63:[addHasEvent, updateContainedRLE] [UpdateTracker:9779010] Update Tracker - [Pathway:1268020] Mitochondrial protein import - v66:[addLiteratureReference, modifyText] [UpdateTracker:9781349] Update Tracker - [Pathway:1268020] Mitochondrial protein import - v61:[updateContainedRLE] [UpdateTracker:9783868] Update Tracker - [Pathway:1268020] Mitochondrial protein import - v55:[updateContainedRLE]

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