Reactome | TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix

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TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix Show undefined attributes

authored	[InstanceEdit:1299477] May, B, 2011-05-21
catalystActivity	[CatalystActivity:1299479] protein transmembrane transporter activity of TIMM23 PAM:Cargo [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:1299483] May, B, 2011-05-23
dbId	1299475
displayName	TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix
edited	[InstanceEdit:1299477] May, B, 2011-05-21
eventOf	[Pathway:R-HSA-1268020] Mitochondrial protein import - Homo sapiens
inferredFrom	[Reaction:R-SCE-1252253] TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix - Saccharomyces cerevisiae
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [Complex:R-HSA-1299474] TIMM23 PAM:Cargo [mitochondrial inner membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2127552] Step-size analyses of the mitochondrial Hsp70 import motor reveal the Brownian ratchet in operation [LiteratureReference:1307738] Multiple pathways for mitochondrial protein traffic [LiteratureReference:1307739] Multiple pathways for sorting mitochondrial precursor proteins
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix
output	[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [CandidateSet:R-HSA-1299460] Cargo of TIMM23 PAM [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix] [Complex:R-HSA-1252242] TIMM23 Complex [mitochondrial inner membrane]
precedingEvent	[Reaction:R-HSA-1299478] MPP cleaves targeting peptide (presequence) of matrix precursors - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1914221] D'Eustachio, P, 2011-11-01 [InstanceEdit:2108993] Endo, T, 2012-02-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1299475
summation	[Summation:1307724] As inferred from the yeast TIM23 complex, the human TIMM23 c...

Referrals

(hasEvent)	[Pathway:R-HSA-1268020] Mitochondrial protein import
(inferredTo)	[Reaction:R-SCE-1252253] TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix

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