Cleavage of ERBB4m80 by gamma-scretase complex

Stable Identifier
R-HSA-1251997
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Cleavage of ERBB4m80 by gamma-scretase complex
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After ERBB4 is cleaved by ADAM17, gamma-secretase complex performs additional cleavage in the transmembrane region of the m80 ERBB4 fragment, releasing the soluble ERBB4 intracellular domain of 80 kDa, known as s80 or E4ICD (Ni et al. 2001).

Literature References
PubMed ID Title Journal Year
11679632 gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

Golde, TE, Murphy, MP, Carpenter, G, Ni, CY

Science 2001
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Output
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as an event of
Catalyst Activity

endopeptidase activity of gamma-secretase complex [plasma membrane]

Physical Entity
gamma-secretase complex [plasma membrane] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Cleavage of ERBB4m80 by gamma-scretase complex (Bos taurus)
Cleavage of ERBB4m80 by gamma-scretase complex (Caenorhabditis elegans)
Cleavage of ERBB4m80 by gamma-scretase complex (Canis familiaris)
Cleavage of ERBB4m80 by gamma-scretase complex (Danio rerio)
Cleavage of ERBB4m80 by gamma-scretase complex (Drosophila melanogaster)
Cleavage of ERBB4m80 by gamma-scretase complex (Gallus gallus)
Cleavage of ERBB4m80 by gamma-scretase complex (Mus musculus)
Cleavage of ERBB4m80 by gamma-scretase complex (Rattus norvegicus)
Cleavage of ERBB4m80 by gamma-scretase complex (Sus scrofa)
Authored
Orlic-Milacic, M  (2011-11-04)
Stern, DF  (2019-02-21)
Reviewed
Zeng, F  (2011-11-11)
Harris, RC  (2011-11-11)
Earp HS, 3rd  (2012-02-20)
Misior, AM  (2012-02-20)
Created
Orlic-Milacic, M  (2011-04-26)
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