All ERBB2 heterodimers, ERBB2:EGFR, ERBB2:ERBB3 and ERBB2:ER...

created [InstanceEdit:1361854] Orlic-Milacic, Marija, 2011-06-03
dbId 1361852
displayName All ERBB2 heterodimers, ERBB2:EGFR, ERBB2:ERBB3 and ERBB2:ER...
modified [InstanceEdit:1474296] Orlic-Milacic, Marija, 2011-08-05
schemaClass Summation
text All ERBB2 heterodimers, ERBB2:EGFR, ERBB2:ERBB3 and ERBB2:ERBB4, are able to activate RAF/MAP kinase cascade by recruiting SHC1 (Pinkas-Kramarski et al. 1996, Sepp-Lorenzino et al. 1996) to phosphorylated C-tail tyrosine residues in either EGFR (Y1148 and Y1173), ERBB2 (Y1196, Y1221, Y1222 and Y1248), ERBB3 (Y1328) or ERBB4 (Y1188 and Y1242 in JM-A CYT1 isoform, Y1178 and Y1232 in JM-B CYT1 isoform, Y1172 and Y1226 in JM-A CYT2 isoform). SHC1 recruitment is followed by phosphorylation (Segatto et al. 1993, Soler et al. 1994), and the phosphorylated SHC1 recruits GRB2:SOS1 complex (Xie et al. 1995), which leads to SOS1-mediated guanyl-nucleotide exchange on RAS (Xie et al. 1995) and downstream activation of RAF and MAP kinases.
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