Reactome | SHC1 events in ERBB2 signaling

Schema > Pathway > Entries

compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557701
displayName	SHC1 events in ERBB2 signaling
eventOf	[Pathway:R-SSC-1227986] Signaling by ERBB2 - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-1250195] SHC1 phosphorylation by ERBB2 heterodimers - Sus scrofa [Reaction:R-SSC-8934446] Activated PKC phosphorylates SHC1 - Sus scrofa [Reaction:R-SSC-8934465] SHC1 binds PTPN12 - Sus scrofa
inferredFrom	[Pathway:R-HSA-1250196] SHC1 events in ERBB2 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	SHC1 events in ERBB2 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-1250196
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-1227986] Signaling by ERBB2
(inferredTo)	[Pathway:R-HSA-1250196] SHC1 events in ERBB2 signaling

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