Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants

Stable Identifier
R-HSA-1247844
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants
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Once recruited, PLC-gamma 1 is assumed to be phosphorylated by EGFR cancer mutants in the same way it is phosphorylated by the wild-type EGFR.
Literature References
PubMed ID Title Journal Year
2472219 Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

Meisenhelder, J, Rhee, SG, Suh, PG, Hunter, T

Cell 1989
1689311 Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells

Kim, JW, Rhee, SG, Wahl, MI, Kim, H, Nishibe, S, Carpenter, G

J Biol Chem 1990
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane]

Physical Entity
Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Normal reaction
EGFR activates PLC-gamma1 by phosphorylation (Homo sapiens)
Functional status

Gain of function of Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2011-04-07)
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