Reactome | ERBB2 binds trastuzumab

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ERBB2 binds trastuzumab Show undefined attributes

authored	[InstanceEdit:9656339] Orlic-Milacic, Marija, 2019-07-31
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9652267] Orlic-Milacic, Marija, 2019-06-28
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9652277
disease	[Disease:1500689] cancer
diseaseReaction	[FailedReaction:R-HSA-9665232] Resistant ERBB2 KD mutants do not bind trastuzumab - Homo sapiens [Reaction:R-HSA-9665405] ERBB2 ECD mutants bind trastuzumab - Homo sapiens [Reaction:R-HSA-9665696] ERBB2 TMD/JMD mutants bind trastuzumab - Homo sapiens
displayName	ERBB2 binds trastuzumab
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
eventOf	[Pathway:R-HSA-9652282] Drug-mediated inhibition of ERBB2 signaling - Homo sapiens [Pathway:R-HSA-9634285] Constitutive Signaling by Overexpressed ERBB2 - Homo sapiens
input	[Complex:R-HSA-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [ProteinDrug:R-ALL-9634466] trastuzumab [extracellular region]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9652354] p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor [LiteratureReference:9652351] Humanization of an anti-p185HER2 antibody for human cancer therapy [LiteratureReference:9634297] The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2
maxDepth	1
modified	[InstanceEdit:9866055] Orlic-Milacic, Marija, 2024-03-20
name	ERBB2 binds trastuzumab
output	[Complex:R-HSA-9652349] ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane]
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9662685] Kancha, Rama Krishna, 2019-09-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9652277
summation	[Summation:9652268] ERBB2 signaling is inhibited by binding of ERBB2 to ERBB2-di...

Referrals

(hasEvent)	[Pathway:R-HSA-9634285] Constitutive Signaling by Overexpressed ERBB2 [Pathway:R-HSA-9652282] Drug-mediated inhibition of ERBB2 signaling
(normalReaction)	[FailedReaction:R-HSA-9665232] Resistant ERBB2 KD mutants do not bind trastuzumab [Reaction:R-HSA-9665405] ERBB2 ECD mutants bind trastuzumab [Reaction:R-HSA-9665696] ERBB2 TMD/JMD mutants bind trastuzumab