Reactome | PRLR is regulated by ubiquitination of the activated recepto...

Schema > Summation > Entries

created	[InstanceEdit:1302681] Jupe, S, 2011-05-27
dbId	1302696
displayName	PRLR is regulated by ubiquitination of the activated recepto...
literatureReference	[LiteratureReference:1302686] Down-regulation of prolactin receptors in rabbit mammary gland: differential subcellular localization [LiteratureReference:1302694] Prolactin receptor turnover in explants of pseudopregnant rabbit mammary gland [LiteratureReference:1302667] Multiple internalization motifs differentially used by prolactin receptor isoforms mediate similar endocytic pathways [LiteratureReference:1302716] Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase [LiteratureReference:1675478] Regulation of prolactin receptor levels and activity in breast cancer
modified	[InstanceEdit:1675476] Jupe, S, 2011-10-17
schemaClass	Summation
text	PRLR is regulated by ubiquitination of the activated receptor, leading to lysosomal degradation (Djiane et al. 1981, 1982, Lu et al. 2002). Recruitment of the SCFbeta-TrCP ubiquitin ligase complex enables receptor ubiquitination and internalization (Li et al. 2004). This limits the duration and intensity of receptor signaling. Deregulation of this negative control lead to pathological conditions including cancer (Swaminathan et al. 2008).

(summation)

Cite Us!