Prolactin receptor is internalized

Stable Identifier
R-HSA-1170539
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, endosome lumen, extracellular region
ReviewStatus
5/5
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Prolactin receptor is internalized
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PRLR is regulated by ubiquitination of the activated receptor, leading to lysosomal degradation (Djiane et al. 1981, 1982, Lu et al. 2002). Recruitment of the SCFbeta-TrCP ubiquitin ligase complex enables receptor ubiquitination and internalization (Li et al. 2004). This limits the duration and intensity of receptor signaling. Deregulation of this negative control lead to pathological conditions including cancer (Swaminathan et al. 2008).
Literature References
PubMed ID Title Journal Year
15082796 Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase

Fuchs, SY, Spiegelman, VS, Tang, W, Li, Y, Kumar, KG

Mol Cell Biol 2004
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Orthologous Events
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Authored
Jupe, S  (2011-06-13)
Reviewed
Goffin, V  (2011-11-08)
Created
Jupe, S  (2011-01-19)
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