Prolactin receptor is internalized

Stable Identifier
R-HSA-1170539
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PRLR is regulated by ubiquitination of the activated receptor, leading to lysosomal degradation (Djiane et al. 1981, 1982, Lu et al. 2002). Recruitment of the SCFbeta-TrCP ubiquitin ligase complex enables receptor ubiquitination and internalization (Li et al. 2004). This limits the duration and intensity of receptor signaling. Deregulation of this negative control lead to pathological conditions including cancer (Swaminathan et al. 2008).

Literature References
PubMed ID Title Journal Year
15082796 Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase

Li, Y, Kumar, KG, Tang, W, Spiegelman, VS, Fuchs, SY

Mol Cell Biol 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!