Reactome | Activated FGFR2 binds SHC1

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Activated FGFR2 binds SHC1 Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654400] Rothfels, Karen, 2014-12-03
dbId	5654404
deleted	[Deleted:5655550] Deletion of instance: 1268226
displayName	Activated FGFR2 binds SHC1
eventOf	[Pathway:R-HSA-5654699] SHC-mediated cascade:FGFR2 - Homo sapiens
followingEvent	[Reaction:R-HSA-5654407] Activated FGFR2 phosphorylates SHC1 - Homo sapiens
input	[DefinedSet:R-HSA-5654152] Activated FGFR2 [plasma membrane] [DefinedSet:R-HSA-1169480] SHC1-2,SHC1-3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:532244] Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells [LiteratureReference:191036] Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells [LiteratureReference:191526] Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein. [LiteratureReference:532248] Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2)
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Activated FGFR2 binds SHC1
orthologousEvent	[Reaction:R-DME-5654404] Activated FGFR2 binds SHC1 - Drosophila melanogaster [Reaction:R-GGA-5654404] Activated FGFR2 binds SHC1 - Gallus gallus [Reaction:R-BTA-5654404] Activated FGFR2 binds SHC1 - Bos taurus [Reaction:R-CFA-5654404] Activated FGFR2 binds SHC1 - Canis familiaris [Reaction:R-RNO-5654404] Activated FGFR2 binds SHC1 - Rattus norvegicus [Reaction:R-MMU-5654404] Activated FGFR2 binds SHC1 - Mus musculus
output	[Complex:R-HSA-5654279] Activated FGFR2:SHC1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-190408] Autocatalytic phosphorylation of FGFR2b - Homo sapiens [Reaction:R-HSA-190413] Autocatalytic phosphorylation of FGFR2c - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654404
summation	[Summation:1268224] Although a role for SHC1 in FGF signalling has been implicat...

Referrals

(replacementInstances)	[Deleted:5655550] Deletion of instance: 1268226
(hasEvent)	[Pathway:R-HSA-5654699] SHC-mediated cascade:FGFR2
(precedingEvent)	[Reaction:R-HSA-5654407] Activated FGFR2 phosphorylates SHC1