Reactome | ISGylation of E2 conjugating enzymes

ISGylation of E2 conjugating enzymes

Stable Identifier

R-HSA-1169402

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Ubiquitin conjugating E2 enzymes UBC13 and UBCH6 are targets for ISGylation. This suppresses the ubiquitin-conjugating activity of both UBC13 and UBCH6. This modification may play an important role in the control of signal transduction pathways, such as the NF-kB pathway, which are associated with K63-linked polyubiquitination (Takeuchi et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
16112642	ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity Takeuchi, T, Yokosawa, H	Biochem Biophys Res Commun	2005
16428300	Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme Takeuchi, T, Iwahara, S, Saeki, Y, Sasajima, H, Yokosawa, H	J Biochem	2005
16122702	ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin Zou, W, Papov, V, Malakhova, O, Kim, KI, Dao, C, Li, J, Zhang, DE	Biochem Biophys Res Commun	2005