Reactome | ISGylation of E2 conjugating enzymes

Schema > Reaction > Entries

ISGylation of E2 conjugating enzymes Show undefined attributes

catalystActivity	[CatalystActivity:10358385] ubiquitin-protein transferase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
dbId	10358410
displayName	ISGylation of E2 conjugating enzymes
eventOf	[Pathway:R-SSC-1169408] ISG15 antiviral mechanism - Sus scrofa
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1169402] ISGylation of E2 conjugating enzymes - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-SSC-1169378] E2 congugating enzymes [cytosol] [Complex:R-SSC-1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol]
isInDisease	false
isInferred	true
name	ISGylation of E2 conjugating enzymes
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [CandidateSet:R-SSC-1169381] ISG15 E3 ligases [cytosol] [Complex:R-SSC-1169382] ISGylated E2 conjugating enzymes [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol] [EntityWithAccessionedSequence:R-SSC-936014] UBE2L6 [cytosol]
precedingEvent	[Reaction:R-SSC-1169403] Interaction of E3 ligase with ISG15:E2 complex - Sus scrofa
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-1169402
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1169408] ISG15 antiviral mechanism
(inferredTo)	[Reaction:R-HSA-1169402] ISGylation of E2 conjugating enzymes