p115-RhoGEF is a potent GTPase activating protein (GAP) for both G alpha 12 and G alpha 13 subunits. More importantly, the interaction between activated G alpha 13 (but not G alpha 12) triggers p115-RhoGEF activity. While this pathway may be important in vivo, in prostate-derived PC-3 cells RNAi mediated knockdown of p115-RhoGEF levels had no effect on the response to thrombin (Wang et al. 2004).
Fukuhara, S, Chikumi, H, Gutkind, JS
Siderovski, DP, Willard, FS
Chen, Z, Guo, L, Hadas, J, Gutowski, S, Sprang, SR, Sternweis, PC
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