Reactome | G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)

G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)

Stable Identifier

R-HSA-114548

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)

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p115-RhoGEF is a potent GTPase activating protein (GAP) for both G alpha 12 and G alpha 13 subunits. More importantly, the interaction between activated G alpha 13 (but not G alpha 12) triggers p115-RhoGEF activity. While this pathway may be important in vivo, in prostate-derived PC-3 cells RNAi mediated knockdown of p115-RhoGEF levels had no effect on the response to thrombin (Wang et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15951850	The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits Siderovski, DP, Willard, FS	Int J Biol Sci	2005
11313914	RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho? Fukuhara, S, Chikumi, H, Gutkind, JS	Oncogene	2001
22661716	Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain Chen, Z, Guo, L, Hadas, J, Gutowski, S, Sprang, SR, Sternweis, PC	J. Biol. Chem.	2012