Reactome | G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)

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G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10234810
displayName	G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
eventOf	[Pathway:R-CFA-416482] G alpha (12/13) signalling events - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-114544] p115-RhoGEF activation of RHOA - Canis familiaris [Reaction:R-CFA-419166] GEFs activate RhoA,B,C - Canis familiaris
inferredFrom	[Reaction:R-HSA-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-114526] ARHGEF1 [cytosol] [Complex:R-CFA-398056] G-protein alpha (13):GTP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
output	[Complex:R-CFA-114527] G13-activated p115-RhoGEF [plasma membrane]
precedingEvent	[Reaction:R-CFA-380073] Liganded Gi-activating GPCR acts as a GEF for Gi - Canis familiaris [Reaction:R-CFA-397891] Thrombin-activated PARs:G12/13 (active) dissociate - Canis familiaris [Reaction:R-CFA-428918] Dissociation of the TP:G13 complex - Canis familiaris [Reaction:R-CFA-751019] The Ligand:GPCR:G12/13 complex dissociates - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-114548
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-416482] G alpha (12/13) signalling events
(precedingEvent)	[Reaction:R-CFA-114544] p115-RhoGEF activation of RHOA [Reaction:R-CFA-419166] GEFs activate RhoA,B,C
(inferredTo)	[Reaction:R-HSA-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)

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