p115-RhoGEF activation of RHOA

Stable Identifier
R-HSA-114544
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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p115-RhoGEF activation of RHOA
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ARHEF1 (p115-RhoGEF), recruited to the plasma membrane by binding to GTP-bound G-protein alpha (13) (GNA13), stimulates GDP to GTP exchange on RHOA, resulting in activation of the RHOA GTPase (Chen et al. 2012).
Literature References
PubMed ID Title Journal Year
22661716 Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain

Chen, Z, Guo, L, Hadas, J, Gutowski, S, Sprang, SR, Sternweis, PC

J. Biol. Chem. 2012
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Catalyst Activity

guanyl-nucleotide exchange factor activity of G13-activated p115-RhoGEF [plasma membrane]

Physical Entity
G13-activated p115-RhoGEF [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
p115-RhoGEF activation of RHOA (Bos taurus)
p115-RhoGEF activation of RHOA (Caenorhabditis elegans)
p115-RhoGEF activation of RHOA (Canis familiaris)
p115-RhoGEF activation of RHOA (Drosophila melanogaster)
p115-RhoGEF activation of RHOA (Gallus gallus)
p115-RhoGEF activation of RHOA (Mus musculus)
p115-RhoGEF activation of RHOA (Rattus norvegicus)
p115-RhoGEF activation of RHOA (Sus scrofa)
Created
de Bono, B  (2004-09-25)
Pace, NP  (2004-09-25)
Farndale, R  (2004-09-25)
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