p115-RhoGEF activation of RHOA

Stable Identifier
R-HSA-114544
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ARHEF1 (p115-RhoGEF), recruited to the plasma membrane by binding to GTP-bound G-protein alpha (13) (GNA13), stimulates GDP to GTP exchange on RHOA, resulting in activation of the RHOA GTPase (Chen et al. 2012).

Literature References
PubMed ID Title Journal Year
22661716 Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain

Chen, Z, Guo, L, Hadas, J, Gutowski, S, Sprang, SR, Sternweis, PC

J. Biol. Chem. 2012
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of G13-activated p115-RhoGEF [plasma membrane]

Orthologous Events
Created
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