Reactome | p115-RhoGEF activation of RHOA

Schema > Reaction > Entries

p115-RhoGEF activation of RHOA Show undefined attributes

catalystActivity	[CatalystActivity:10921802] guanyl-nucleotide exchange factor activity of G13-activated p115-RhoGEF [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10921804
displayName	p115-RhoGEF activation of RHOA
eventOf	[Pathway:R-CEL-416482] G alpha (12/13) signalling events - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-114544] p115-RhoGEF activation of RHOA - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-CEL-8964174] RHOA:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	p115-RhoGEF activation of RHOA
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-CEL-5665993] RHOA:GTP [plasma membrane]
precedingEvent	[Reaction:R-CEL-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-114544
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-416482] G alpha (12/13) signalling events
(inferredTo)	[Reaction:R-HSA-114544] p115-RhoGEF activation of RHOA