Reactome | RAF-independent MAPK1/3 activation

Schema > Pathway > Entries

RAF-independent MAPK1/3 activation Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10993795
displayName	RAF-independent MAPK1/3 activation
eventOf	[Pathway:R-CEL-5684996] MAPK1/MAPK3 signaling - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:396352] ERK1 and ERK2 cascade
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-CEL-110056] MAPK3 (ERK1) activation - Caenorhabditis elegans [Pathway:R-CEL-112411] MAPK1 (ERK2) activation - Caenorhabditis elegans [Reaction:R-CEL-5674385] p-T,Y MAPKs dimerize - Caenorhabditis elegans [BlackBoxEvent:R-CEL-5674387] Phosphorylated MAPKs translocate into the nucleus - Caenorhabditis elegans [Reaction:R-CEL-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-112409] RAF-independent MAPK1/3 activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	RAF-independent MAPK1/3 activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-112409
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-5684996] MAPK1/MAPK3 signaling
(hasEncapsulatedEvent)	[Pathway:R-CEL-450294] MAP kinase activation
(inferredTo)	[Pathway:R-HSA-112409] RAF-independent MAPK1/3 activation

Cite Us!