Reactome | CBL [cytosol]

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CBL [cytosol] Show undefined attributes

candidateOf	[CandidateSet:R-GGA-8876356] CBL:GRB2,CBL [cytosol] - Gallus gallus
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-GGA-8876350] HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] - Gallus gallus [Complex:R-GGA-1112744] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] - Gallus gallus
consumedByEvent	[Reaction:R-GGA-205244] Recruitment of CBL to KIT - Gallus gallus [Reaction:R-GGA-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated - Gallus gallus [BlackBoxEvent:R-GGA-182988] Sprouty lures CBL away from EGFR - Gallus gallus [Reaction:R-GGA-183052] CBL binds to GRB2 - Gallus gallus [Reaction:R-GGA-183055] Binding of CBL to EGFR - Gallus gallus [Reaction:R-GGA-183055] Binding of CBL to EGFR - Gallus gallus [Reaction:R-GGA-1112690] PTPN11 binds CBL - Gallus gallus [Reaction:R-GGA-183094] CDC42:GTP binds CBL:Beta-Pix - Gallus gallus [Reaction:R-GGA-4332235] CBL binds TGFBR2 - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10744561
displayName	CBL [cytosol]
endCoordinate	906
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-112199] CBL [cytosol] - Homo sapiens
maxDepth	1
name	CBL CBL A0A8V0ZY53
producedByEvent	[Reaction:R-GGA-1295621] CBL dissociates from ubiquitinated p-SPRY2 - Gallus gallus
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8V0ZY53] UniProt:A0A8V0ZY53
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49591] Gallus gallus
stId	R-GGA-112199
startCoordinate	1

Referrals

(hasCandidate)	[CandidateSet:R-GGA-8876356] CBL:GRB2,CBL [cytosol]
(hasComponent)	[Complex:R-GGA-8876350] HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] [Complex:R-GGA-205200] CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] [Complex:R-GGA-912623] FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-GGA-1112744] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] [Complex:R-GGA-934572] Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] [Complex:R-GGA-934576] Y55/Y227-pSPRY2:CBL [plasma membrane] [Complex:R-GGA-182956] CBL:Beta-Pix:CDC42:GTP [cytosol] [Complex:R-GGA-182914] CBL:SPRY1/2 [cytosol] [Complex:R-GGA-182910] CBL:GRB2 [cytosol] [Complex:R-GGA-182960] EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] [Complex:R-GGA-4332229] TGFBR2:CBL [plasma membrane]
(input)	[Reaction:R-GGA-205244] Recruitment of CBL to KIT [Reaction:R-GGA-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated [Reaction:R-GGA-1112690] PTPN11 binds CBL [Reaction:R-GGA-183094] CDC42:GTP binds CBL:Beta-Pix [BlackBoxEvent:R-GGA-182988] Sprouty lures CBL away from EGFR [Reaction:R-GGA-183052] CBL binds to GRB2 [Reaction:R-GGA-183055] Binding of CBL to EGFR [Reaction:R-GGA-4332235] CBL binds TGFBR2
(output)	[Reaction:R-GGA-1295621] CBL dissociates from ubiquitinated p-SPRY2
(activeUnit)	[CatalystActivity:10764275] ubiquitin protein ligase activity of Y55/Y227-pSPRY2:CBL [plasma membrane] [CatalystActivity:10744637] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-112199] CBL [cytosol]

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